Special Geriatric Psychiatry Section GABAergic Function in Alzheimer’s Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia
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چکیده
A lzheimer’s disease (AD) is the most common type of dementia (1,2) and is characterized by cognitive deficits and behavioural and psychological symptoms. These behavioural and psychological symptoms of dementia (BPSD) include delusions, hallucinations, aggression, aberrant motor behaviour, sleep disruptions, agitation, depression, and apathy (3,4). Research in the pathobiology of AD has revealed a gross disruption of neurotransmitter systems (5), including the cholinergic (4) and serotonergic (6,7) systems in both cor-
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تاریخ انتشار 2004